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Scientists at University of Manchester make massive breakthrough on dementia

A massive step forward in the search for a cure for dementia

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Scientists at the University of Manchester have discovered that a common blood pressure drug that could help people suffering from vascular dementia.

Amlodepine is used to treat high blood pressure, but could potentially serve a purpose in tackling a type of vascular dementia caused by damaged and ‘leaky’ small blood vessels in the brain, according to research part-funded by the British Heart Foundation and published today in the Journal of Clinical Investigation.

High blood pressure is known to be the main risk factor in developing vascular dementia.

Researchers came to their conclusion by analysing blood flow in the brains of mice with high blood pressure and vascular damage in the brain.

@officialuom / Instagram

Mice treated with amlodipine had better blood flow to more active areas of the brain. Their arteries were able to widen, allowing more oxygen and nutrients to reach the parts of the brain that needed it most.

The team also discovered for the first time that high blood pressure decreases the activity of a protein called ‘Kir2.1’ that is present in cells lining the blood vessels and increases blood flow to active areas of the brain.

They now hope to trial amlodipine as an effective treatment for vascular dementia in humans, making it the first clinically proven treatment for vascular dementia if successful. 

Dr Adam Greenstein, Clinical Senior Lecturer in Cardiovascular Sciences at the University of Manchester, who led the Manchester team, told ITV News: “The way vascular dementia develops has remained a mystery until now, and there are currently no clinically proven treatments.

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“Patients are presenting with symptoms of vascular dementia earlier than ever before, and with further research we could potentially offer those patients hope to prevent the progression of this life-changing disease.”

Professor Metin Avkiran, Associate Medical Director at the British Heart Foundation, added: “The way to better understand this devastating disease and find new treatments is through research. This study is a vital step forward towards finding new ways of stopping vascular dementia from progressing.

“These new discoveries highlight the major role that high blood pressure plays in developing the disease and shed light on how this occurs and might be prevented in the future.”

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Every Covid restriction including self-isolation ‘to end in March’

JUST IN: All restrictions are set to be lifted in March

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Boris Johnson is drawing up plans to bring all Covid restrictions including self-isolation to an end from March, new reports have detailed today.

A senior source has said the Government is considering abandoning all legally-binding restrictions in England and moving to a guidance-based system as it moves towards ‘living with the virus’ like the flu.

The official stated that even the most basic rules could be lifted, such as compulsory self-isolation of cases and the requirement to co-operate with Test and Trace.

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This comes amid reports of the current Plan B restrictions allegedly being scrapped ‘within days’. These include the use of face masks in all shops, schools and on public transport, a work from home order for businesses and the controversial use of Covid passports when travelling.

While the restrictions are set to be reviewed on January 26th, a senior government official said that the measures currently in place under the plan will be lifted.

Speaking anonymously to the Sunday Express, the source said that Health Secretary Sajid Javid ‘feels confident’ about the decision because of the falling number of cases and growing evidence that Omicron is not as dangerous as other variants.

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The source added: “Sajid is sure now that the restrictions will not go beyond the sunset clause date.”

However, there have also been numerous reports that the move could be Boris Johnson’s way of staying in power after he was allegedly told by senior Conservative backbenchers that he would face a leadership vote of confidence if he tried to bring in more restrictions.

101 Conservative MPs reportedly opposed the current restrictions in a Commons rebellion just before Christmas.

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Man tragically dies after falling from apartment block near the city centre

Police attended the scene after reports of a man falling in the early hours of this morning

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A man has sadly died after falling from an apartment block in Salford.

Police were called to Rolling Street – just off of Trinity Way near Manchester city centre – at around 5:10am this morning after receiving reports that a man had fallen from a building.

Upon arrival at the apartment complex, officers found the man and immediately called emergency services.

Despite the best efforts of paramedics, however, the man was pronounced dead at the scene.

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The quiet residential street was sealed off this morning, with two police vehicles seen guarding each side of the cordon.

The cause of the fall is not yet known, though detectives say they are keeping an ‘open mind’ about about the full circumstances of the tragedy.

No arrests have been made and enquiries are said to be ongoing.

A spokesperson for Greater Manchester Police said: “Police were called around 5.10am today (January 18th) to Rolling Street, Salford to a report of a male having fallen from a building.

“Emergency services attended and despite the best efforts of paramedics he was sadly pronounced dead at the scene.

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“Enquiries are ongoing to establish the full circumstances and detectives are keeping an open mind as they investigate.

“No arrests have been made.”

A spokesperson for Get Living, the company that manages the apartment block, added: “We are very sad to confirm a death at New Maker Yards this morning.

“We are working closely with the emergency services who are continuing their investigation and will issue further information as it becomes available.”

Anyone with any information about the incident should contact police on 101 quoting incident 374 of 18/01/22. Alternatively, details can be passed via the LiveChat at www.gmp.police.uk or via the independent charity Crimestoppers on 0800 555 111.

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Bus driver sacked for being ‘too short’ gets job back after winning appeal

Tracey had been driving Manchester buses for over three decades when she was let go for ‘being too short’

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Paul Gerrard & Unite North West / Facebook

The female bus driver who was sacked for being ‘too short’ has been given her job back after winning her highly-publicised appeal.

Despite being one of the first female bus drivers in Manchester and having thirty-four years of experience under her belt, Tracey Scholes was found to lack the ‘capability’ to drive Go North West’s new vehicles safely.

The position of the new buses’ wing mirrors required the fifty-seven-year-old, from Heywood, to lean around a pillar to see them, meaning she could not keep her feet safely on the pedals. 

Because of this, Tracey was offered a different position driving the company’s school buses, though it would mean a reduction in hours worked and pay.

The company also offered the bus driver her current pay rate but with reduced hours, which meant she would still be losing around £230 a month, the Unite union said. She turned down both positions and was subsequently given her notice.

Tracey’s story was quick to go viral and gained the support of celebrities including actors Maxine Peake, Julie Hesmondhalgh and James Quinn. A petition was also set up in support of Tracey has gained a massive 29,214 signatures at the time of writing.

Also at her wit’s end, Tracey herself launched a desperate appeal last week to keep her job, which saw hundreds of people turn out at the Queens Road Depot in Cheetham Hill where the appeal hearing was taking place to show their support.

And this week, the campaigning has paid off, with Go North West officially offering Tracey her job back where she would drive a different model of bus.

Under the new deal, Tracey will start earlier to allow her to pick up a bus with wing mirrors of her preference, and her weekly hours and rate of pay will remain unchanged.

Go North West’s HR director Scott Maynard said in a statement that the company was ‘pleased’ their ‘valued and long-serving driver’ was to stay with Go North West ‘after she decided to accept an offer to drive different buses as per a proposal made in September’. 

Scott Maynard added: “We have said from the start that we wanted to keep Tracey and we are glad that she has changed her mind and decided to stay.”

He said the company “operates no height restrictions on recruitment, and has multiple drivers of the same height, or below, as Tracey”.

“It is categorically untrue that we would, or could, have threatened anybody with dismissal on grounds of height.”

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