New drug donanemab has been found to slow the progression of Alzheimer’s disease with experts hailing it as a ‘turning point’.
Donanemab was found to slow ‘cognitive decline’ by up to 35%, allowing people with the disease to continue performing day-to-day tasks and living an independent life.
Alzheimer’s Research UK said ‘we’re entering a new era’ where the disease ‘could become treatable’ following the findings from a clinical trial of the drug.
The medication works by clearing a protein that builds up in the brains of people with the disease.
Although it’s not a cure, the Alzheimer’s Society said treatments such as donanemab could one day mean the disease is comparable to long-term conditions such as asthma or diabetes.
A health watchdog is already assessing whether the drug could be used in the NHS.
Researchers examined almost 1,800 people with early-stage Alzheimer’s for the trial — known as TRAILBLAZER ALZ-2.
Half of those who participated were given a monthly infusion of donanemab into the bloodstream and the other half given a placebo over a period of 18 months.
After the study concluded, it showed donanemab slowed clinical decline by about a third of people with early Alzheimer’s whose brain scans showed low or medium levels of a protein called tau.
When the results were combined for people who had different levels of this protein, there was a 22.3% slowing in the progression of the disease. Although extremely promising, these drugs are not risk-free treatments.
Researchers found among a small number of people there were some serious side effects such as brain swelling. Three volunteers died, one being in the placebo group, as a result of dangerous swelling in the brain.
Manufacturers of donanemab, US pharmaceutical giant Eli Lilly, said some taking the drug would be able to finish the course of treatment in six months once their amyloid plaque cleared.
It said treatment with the drug reduced amyloid plaque on average by 84% at 18 months, compared with a 1% decrease for participants who were given a placebo. Almost half of those taking the drug who had early-stage disease and low or medium levels of tau were found to slow the disease for a year.
It comes after trials showed another drug called lecanemab stalled progression of Alzheimer’s symptoms by over a quarter in patients in the early stages of the disease. The drug was approved for use in the US this month.
Dr Mark Mintun, group vice president of neuroscience research and development at Eli Lilly and president of Avid Radiopharmaceuticals, said: “People living with early, symptomatic Alzheimer’s disease are still working, enjoying trips, sharing quality time with family – they want to feel like themselves, for longer.
“The results of this study reinforce the importance of diagnosing and treating disease sooner than we do today.”
Celebrate Embankment Kitchen’s fourth birthday with prizes to be won throughout October
There’s some fantastic prizes to be won throughout the whole month
Manchester restaurant, bar & grill Embankment Kitchen is celebrating its fourth birthday, where diners will receive a scratch card to win a variety of prizes throughout October.
Celebrations kick off on Wednesday, October 4th at the sophisticated venue, located in the CitySuites Aparthotel, and will continue throughout the entire month.
The birthday month will feature live music every Thursday, a special birthday cocktail menu, and the chance to win some big prizes too.
Diners also receive 25% off* their food bill, throughout October, every Tuesday to Saturday (*This offer is for the a la carte menu only).
Guests could also find themselves sipping on free beer, prosecco and cocktails, or even enjoying a meal on the house – all to be won on the Embankment birthday scratch cards.
The live music features a range of talented artists performing throughout the evening, from duos covering modern songs to the fabulous gypsy jazz band The String Beans.
Embankment’s special birthday cocktail menu includes the Peach Blossom Bellini, made with Grey Goose Vodka and Baron de Marck Champagne, with notes of Peach and Rosemary.
Sip on the delightful A Toast To 4, made with Beefeater gin, strawberry and lemon flavours and topped with Baron de Marck Champagne.
The EK Sour is made with Havana 7, Disaronno, Lemon, Pineapple, and the Birthday Bubbles cocktail is made with Tanqueray 10, Aperol, Passionfruit, Lemon, Soda – perfect for the celebration.
Guests who chose to dine at Embankment Kitchen throughout October will receive a scratch card with one of the below prizes:
- 15% off food (*Food only. Not valid in conjunction with any other offer or set menu)
- Free beer or prosecco
- Free cocktail
- Free starter or dessert (*When dining with a main)
- Your meal on Embankment – x2
To book a table and celebrate with Embankment and be in with the chance to win great prizes, click HERE.
Embankment Kitchen, CitySuites Aparthotel, 16 Chapel St, Salford
Sunak announces HS2 leg to Manchester to be scrapped
Rishi Sunak announces at the Tory party conference that the Birmingham to Manchester leg of the HS2 is to be scrapped.
The Prime Minister made a key speech at the conference held in Manchester city centre where he confirmed the rail line will stop in Manchester but from Birmingham it will switch onto using the existing West Coast Mainline track.
This means the high speed route, to connect the north with the south, will no longer exist, effectively confirming days of speculation.
After being introduced by his wife, Akshata Murty, as a ‘wonderful father, my best friend, your prime minister’, Mr Sunak thanked both his wife and the audience.
Speaking live from Manchester, Mr Sunak called HS2 the ‘ultimate example of the old consensus’.
The Prime Minister then said he’s cancelling ‘the rest of the HS2 project’ – which means everything outside the London to Birmingham leg, and is currently under construction.
He then said he ‘will reinvest every single penny’ saved from HS2 – £36 billion pounds – into hundreds of new transport projects in the North and in the Midlands, as well as across the country.
He went on to say that the north would benefit from the new projects rather than HS2, saying he ‘challenges anyone to tell me with a straight face that all of that isn’t what the north really needs’.
Mr Sunak said: “With our new Network North, you will be able to get from Manchester to the new station in Bradford in 30 minutes, Sheffield in 42 minutes, and to Hull in 84 minutes on a fully, electrified line.”
He continued: “So those who wish to disagree with me, I respect that. But they should have the honesty to admit that they would now be cancelling the hundreds of alternative projects right across the country that people will benefit from instead.
“I think our plan is simply a better long term investment of £36 billion pounds of taxpayers money.”
He also said that he will keep single bus fares capped at £2 ‘across the whole country’.
The prime minister added: “I say, to those who backed the project in the first place, the facts have changed. And the right thing to do when the facts change, is to have the courage to change direction.
The anticipated announcement came after defence secretary Grant Shapps suggested a change in HS2 plans was thanks to fewer people travelling into work and instead choosing to work from home, following the coronavirus pandemic.
Greater Manchester Mayor Andy Burnham has labelled the, now confirmed, decision as ‘disgraceful’.
Gary Neville welcomes new £400m five-star hotel and residences to Manchester
The world famous W Hotel and W Residences will open in 2027
Exciting first look images are revealed for the hugely anticipated £400 million five-star hotel and residency set to open in 2027.
Gary Neville’s Relentless Developments has announced the St Michael’s development, currently being built between Deansgate and Albert Square, will be bringing with it a world famous hotel brand
The St Michael’s plot, soon to be home to luxury W Hotels and W Residences, will be the first outside London and one of 20 around the world, in a major deal with Marriott International.
The glossy new arrival will see hotel-inspired living offered at St Michael’s 217 apartments, offering buyers the opportunity to purchase a permanent residence within Manchester’s most exclusive postcode.
The iconic 41-storey tower will boast a 162-room hotel, with the tower also housing W Residences, a complex of 217 apartments which will be offered for sale from November, with occupancy also in 2027.
The live-in residences will also boast the facilities of the W Hotels, including 24-hour concierge (W’s whenever/wherever service), round-the-clock in-residence dining, laundry and dry cleaning, as well as the hotel’s gyms and other features.
“W Hotel and W Residences are going to put the distinctive 41-storey tower that is No.2 St Michael’s on the global map,” said Neville, Director, Relentless Developments.
“There is no better home for W Hotel in the North of England than Manchester.
“This is a bold city which continues to defy expectations and which embodies the same values of originality and passion that have made the W Hotel experience world-renowned.
“Situated alongside this, W Residences Manchester will be immersive, design-forward homes that will set a new standard in hotel-inspired living and massively raise the bar for city-centre home ownership.”
“I’d like to thank Marriott International and our developer partner, Salboy, for seeing the potential in this scheme and remaining committed to our vision,” he added.