Dexamethasone is a cheap and widely available drug that can save the lives of patients who have become seriously ill with coronavirus, according to new research.
UK experts are calling this a major breakthrough in the fight against the deadly virus. The low-dose steroid treatment can cut the risk of death by a third for patients on ventilators. For those on oxygen, it can cut deaths by a fifth, the BBC reports.
The drug is part of the world’s biggest trial that is testing existing treatments to see if they could also successfully work on the coronavirus.
Research has shown that if this drug had been used to treat patients in the UK from the start of the coronavirus pandemic, up to 5,000 lives could have been saved.
The drug is also cheap enough meaning it could have huge benefits to poorer countries that are struggling with high numbers of COVID-19 patients.
Most patients (19 out of 20) recover from coronavirus without being admitted to hospital, but some of those that do need oxygen or mechanical ventilation. It is these high-risk patients that dexamethasone could help.
The drug is currently used to reduce inflammation in a range other conditions. It also appears to help stop some of the damage that happens when the body’s immune system goes into overdrive. This over-reaction is called cytokine storm and can be deadly.
In the trial at Oxford University, 2,000 hospital patients were given dexamethasone compared to more than 4,000 who didn’t receive it.
For patients on ventilators, it cut the risk of death from 40% to 28%. For patients needing oxygen, it cut the risk of death from 25% to 20%.
Chief investigator Prof Peter Horby said: “This is the only drug so far that has been shown to reduce mortality – and it reduces it significantly. It’s a major breakthrough.”
Lead researcher, Prof Martin Landray says the findings suggest that for every eight patients on ventilators you could save one life. For patients on oxygen, you could save one life for approx. every 20-25 people treated with the drug.
Pro Landray said: “There is a clear, clear benefit. The treatment is up to 10 days of dexamethasone and it costs about £5 per patient. So essentially it costs £35 to save a life. This is a drug that is globally available.”
Dexamethasone does not appear to help people with milder symptoms of coronavirus – those who don’t need help with their breathing.
Dexamethasone has been used since the early 1960s, treating a wide range of conditions and its new use for coronavirus could have massive impacts across the world.
Currently, half of all COVID-19 patients require a ventilator do not survive, Dexamethasone could cut this number by a third which would have a massive impact.
Elf Bar vapes removed from supermarket shelves after illegal nicotine levels found
Experts described the findings as ‘deeply disturbing’ and warned of a risk to young people illegally using the vapes.
Elf Bar vapes have been removed from major supermarket shelves after being found to be 50% over the legal nicotine limit.
The vapes have been taken off the shelves after the company admitted to ‘inadvertently’ selling products in the UK with legal levels of nicotine in them, a Daily Mail investigation has revealed. The disposable ELFBAR 600s were found to have at least 50% more than the legal limit for nicotine e-liquid.
Chinese vaping giant Elf Bar ‘wholeheartedly apologised’ after independent lab tests by the Daily Mail found its ‘600’ line of its disposable e-pens were at least 50% over the legal limit for nicotine. Experts described the findings as ‘deeply disturbing’ and warned of a risk to young people illegally using the vapes, which are sold by major supermarkets.
UK supermarkets including Tesco, Sainsbury’s, Asda and Morrisons stores, did stock the vapes but most have now confirmed that they have removed them. According to ITV, a Tesco spokesperson said: “We have temporarily removed one ELFBAR vape line from sale as a precautionary measure, whilst the manufacturer urgently investigates these claims.”
Sainsbury’s followed suit with a spokesperson saying: “We are in close contact with our supplier and have temporarily removed the affected Elf Bar product whilst they investigate further.”
A Morrisons spokesperson said: “We are taking this very seriously and we can confirm that we’re working closely with ELFBAR and Trading Standards to investigate this further.” With Asda confirming that they were ‘working with the supplier to investigate the matter’.
It is illegal for under-18s to buy vapes but with the brightly coloured packaging, a variety of flavours and sweet smells, it is no surprise they have become popular amongst young people.
A survey carried out by Action on Smoking and Health (ASH) found that in 2022, 15.8% of 11-17 year olds had tried vaping, compared to 11.2% in 2021 and 13.9% in 2020. ASH also found that in 2022, 7.0% of 11-17 year olds were current users, compared to 3.3% in 2021 and 4.1% in 2020.
A Department for Social Care spokesperson stated that ‘local enforcement agencies’ are responsible for the regulation of such products.
They added that these agencies also have a duty of ‘taking action’ against non-compliant products including products that ‘do not comply’ with the 2ml nicotine limits.
Lap dancing club has licence renewed after claims it makes Manchester look ‘seedy’
The strip club has had its licence renewed despite objections from a local resident.
A lap dancing club in Manchester city centre has recently had its licence renewed despite claims from a local objector that it brings the area into ‘disrepute’ and makes it look ‘seedy’.
The ‘sexual entertainment’ venue based on Whitworth Street West, Deansgate, had its application for renewal granted by Manchester City Council despite objections from a local resident, as reported by the Manchester Evening News.
The resident claimed that the club’s proximity to Deansgate train station brings the city into ‘disrepute’, and that it ‘seems strange’ that visitors and children ‘have to walk past the front door of such a repulsive establishment as they form their first impression of Manchester’.
The sex establishment is located in close proximity to Deansgate Station, where many visitors and commuters get on and off the train in Manchester city centre. Representatives of the club dismissed the objection, arguing that it is based on ‘moral grounds’ which are not relevant to the local authority’s decision.
In an email, the objector – whose name is redacted in papers published by the council – calls for the club to move elsewhere, saying: “I live in Deansgate ward and have frequently thought that the presence of the strip club Obsessions, on the doorstep of one of our big intercity stations, brings the area into disrepute. Its exterior is poorly maintained, hinting at the seedy activity that occurs within.
“It seems very strange that visitors to our beautiful and culturally rich city centre, including international visitors and families with children, have to walk past the front door of such a repulsive establishment as they form their first impression of Manchester.
“I feel strongly that such a business should not be permitted such visibility, and that another location should be found for it. For these reasons, it is the duty of the council to take the opportunity of the licence expiring to rid Deansgate of this unsavoury enterprise.”
Speaking on behalf of the club at a town hall hearing on Monday February 6th, Heath Thomas said Obsessions has been licensed since 2006 and that the character of the area has not changed during that time. He also argued that the objection is on ‘moral grounds’ which is not a reason to refuse the licence.
Mr Thomas told the licensing panel that the property is maintained and is not an ‘eyesore’ locally, and that the police recently inspected the premises and confirmed it is meeting all of the conditions of its licence. No other objections were received in response to the application to renew the club’s sex establishment licence, as Mr Thomas added: “It is just this one email.”
Another lap dancing club in the city centre – Victoria’s in Dantzic Street – also had its licence renewed on Monday February 6th, with no objections received.
Nicola Bulley: Private dive team brought in as last images of missing mum released
Private dive teams have join the search to help find Nicola.
A team of private divers have joined search efforts to find missing mum, Nicola Bulley as last images of her from her doorbell camera have been released.
In what is now into the 10th day of the search for the missing mum-of-two, divers from the private Specialist Group International (SGI) are now assisting Lancashire Police. The firm’s founder, Peter Faulding, said he had offered the team’s services free of charge to the force.
The 45-year-old mum was last seen by a member of the public on a riverside dog walk in St Michael’s on Wyre, in Lancashire, on Friday January 27th. Police believe she may have fallen into the River Wyre.
The mortgage advisor was captured on the doorbell camera of her home as she went on the school run before her disappearance. The images show her getting ready to set off on the four-mile journey from her home. Dressed in her walking boots and hooded raincoat, she is seen opening the boot of the family car as her dog, Willow, jumps in the back.
The private team of drivers have already been scouring the water as they join a team of volunteers, along with mountain rescue, sniffer dogs, drones and helicopters, but no trace of Ms Bulley has yet been found. The firm’s founder, Peter Faulding said: “We’re bringing extra divers, and we also bring hi-tech sonar.
“It gives us double the resources so we can cover an extremely large area.”
Police said SGI’s offer to assist in the search was ‘taken up after speaking with Nicola’s family’, saying: “We continue to lead an extensive and far-reaching multi-agency search using a wide range of specialist equipment and resources.”
Hoping the extra help would bring the family ‘answers’, friend, Emma Wight, added: “Following the theory or hypothesis of the police that Nicola is in the river, we need some evidence to back that up either way.”
After she was last sighted, Ms Bulley’s phone was found on a bench by the Wyre, along with a dog harness, some 25 minutes later.
It was still logged in to a conference call.
Lancashire Police have said there was no evidence of ‘anything untoward’ happening to her or any third-party involvement.
With Detective Superintendent Sally Riley saying officers were ‘as sure as we can be that Nicola has not left the area where she was last seen and that very sadly for some reason she has fallen into the water’.
Detectives said they were open to new information and criticised the online abuse of people who had been helping their inquiry, declaring it ‘totally unacceptable’.
Ms Bulley’s disappearance has drawn a lot of attention on social media with thousands of people commenting on the ongoing search. Many have wished the family well while some people have been speculating about what might have happened by discussing the family’s finances and relationships.
According to the BBC, Ms Bulley’s friend Heather Gibbons said ‘vile’ theories being shared online were hurtful, and that she was concerned that as Ms Bulley’s daughters get older ‘they will be able to look back and they will be able to see everything that was said’.
As reported by the Manchester Evening News, a spokesperson for Lancashire Police said: “The speculation and abuse on social media aimed at some people who are merely assisting our enquiry is totally unacceptable.
“We would urge people to remember that we are investigating the disappearance of Nicola, and the priority is Nicola and her family. We want to find her and provide answers to her family.”